Abstract

The mandibular necrosis seen in cancer pathologies following chemotherapy is a subject of interest to the whole biomedical community and specially dentists, who in the face of this problem don’t find the solution in any routine treatment, since mandibular necrosis is initiated by any dental treatment and goes on until the entire mandible and occasionally the maxilla is damaged. In this work try to elucidate the process originating mandibular necrosis when patients treated with bisphosphonates after chemotherapy, undergo dental treatment. Therefore, healthy bone will also be studied in order to make a comparison. Necrosed and healthy bones were obtained by donation after medical biopsy. Bone was prepared for light microscopy, scanning electron microscopy (SEM) and X-ray energy dispersive spectrometry (EDS). The comparison of the necrosed and healthy bone indicated morphological and chemical differences. The electron microscopy and chemical analysis observations supported this. We can state that in necrosis vasculature collapses as indicated by other authors, but we suggest the circulatory lack alters severely the bone remodeling mainly in the alveoli, affecting the soft tissues feedback with bone and thus all of the tissue is lost.